John J McGuire Selected Research

Bridged-Ring Compounds

12/2006

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.

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John J McGuire Research Topics

Disease

10	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 10/2014
7	Neoplasms (Cancer) 11/2005 - 04/2002
4	Inflammation (Inflammations) 01/2023 - 02/2010
3	Leukemia 12/2006 - 01/2003
2	Type 2 Diabetes Mellitus (MODY) 12/2022 - 01/2021
2	Body Weight (Weight, Body) 12/2017 - 01/2010
2	Obesity 01/2017 - 01/2016
2	Stroke (Strokes) 02/2010 - 05/2007
2	Hypertension (High Blood Pressure) 10/2008 - 07/2007
1	Peripheral Arterial Disease 01/2023
1	Proteinuria 01/2021
1	Hypoxia (Hypoxemia) 01/2019
1	Hypertensive Encephalopathy 02/2010
1	Vascular System Injuries 02/2010
1	Cerebral Hemorrhage 02/2010
1	Edema (Dropsy) 02/2010
1	Rheumatoid Arthritis 04/2009
1	Hemorrhagic Stroke 05/2007
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2005
1	Hypotension (Low Blood Pressure) 12/2004
1	Vascular Diseases (Vascular Disease) 01/2004
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2003
1	Colonic Neoplasms (Colon Cancer) 01/2003

Drug/Important Bio-Agent (IBA)

11	PAR-2 ReceptorIBA 12/2022 - 01/2004
5	Folic Acid AntagonistsIBA 04/2009 - 05/2002
4	Vasodilator Agents (Vasodilators)IBA 12/2022 - 07/2007
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 12/2004
4	Folic Acid (Vitamin M)FDA LinkGeneric 04/2009 - 05/2002
4	pyrimidineIBA 11/2005 - 04/2002
3	BradykininIBA 02/2010 - 05/2007
3	CarbonIBA 12/2006 - 12/2004
2	Thromboxane A2 (A2, Thromboxane)IBA 12/2022 - 01/2019
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019 - 07/2007
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2015 - 05/2007
2	EnzymesIBA 04/2009 - 05/2002
2	Angiotensin IIIBA 10/2008 - 05/2007
2	folylpolyglutamate synthetaseIBA 10/2005 - 05/2002
1	Fatty Acid Binding Protein 3IBA 01/2023
1	Biomarkers (Surrogate Marker)IBA 01/2023
1	LipopolysaccharidesIBA 01/2023
1	ozagrelIBA 12/2022
1	Sodium-Glucose Transport ProteinsIBA 01/2021
1	azilsartanIBA 10/2019
1	Angiotensin II Type 1 Receptor BlockersIBA 10/2019
1	Arachidonic Acid (Vitamin F)IBA 01/2019
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2019
1	Serotonin (5 Hydroxytryptamine)IBA 01/2019
1	Methacholine Chloride (Methacholine)FDA Link 01/2019
1	Cysteine (L-Cysteine)FDA Link 12/2018
1	ApelinIBA 12/2018
1	Dihydrotachysterol (AT 10)IBA 12/2017
1	2-furoyl-LIGRLO-amideIBA 04/2017
1	Cyclic GMPIBA 04/2017
1	CytokinesIBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 10/2014
1	CalciumIBA 02/2010
1	2,5-dichloro-4-bromophenol (B 2)IBA 02/2010
1	CarbenoxoloneIBA 02/2010
1	Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)IBA 01/2010
1	LipidsIBA 01/2010
1	Messenger RNA (mRNA)IBA 01/2010
1	AcidsIBA 04/2009
1	Thymidylate SynthaseIBA 04/2009
1	purineIBA 04/2009
1	Hydroxymethyl and Formyl TransferasesIBA 04/2009
1	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 04/2009
1	SaltsIBA 10/2008
1	Calcimycin (A23187)IBA 05/2007
1	Captopril (Capoten)FDA LinkGeneric 05/2007
1	Losartan (Cozaar)FDA LinkGeneric 05/2007
1	Bridged-Ring CompoundsIBA 12/2006
1	AICA ribonucleotide (ZMP)IBA 04/2006
1	thymidylate synthase-dihydrofolate reductaseIBA 11/2005
1	Protein Isoforms (Isoforms)IBA 10/2005
1	Pemetrexed (MTA)FDA Link 12/2004
1	ProstaglandinsIBA 12/2004
1	Indicators and Reagents (Reagents)IBA 12/2003
1	AminopterinIBA 01/2003
1	raltitrexed (D 1694)IBA 01/2003
1	6-methylprednisolone-21-hemisuberate N,N,N'-triethylenediamine amideIBA 01/2003
1	Glutamic Acid (Glutamate)FDA Link 05/2002

Therapy/Procedure

3	Therapeutics 01/2021 - 04/2009
1	Drug Therapy (Chemotherapy) 05/2002